Lisez nos pré-impressions ci-dessous.

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BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons

May 2025

Nahir Guadalupe Gazal et al.

https://doi.org/10.1101/2025.05.09.653215

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Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson’s disease

February 2025

Julie Jacquemyn et al.

https://doi.org/10.1101/2025.02.14.638390

Mutations in SOD1 induce ALS-related phenotypes in 3D iPSC-derived motor neuron (MN) spheroids

January 2025

María José Castellanos-Montiel et al.

https://doi.org/10.1101/2025.01.28.635126

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

January 2024

Sarah Lépine et al.

DOI: https://doi.org/10.1101/2024.01.30.578100

The functional and pathogenic consequences of fibrinogen on human oligodendroglia

June 2024

G. Blaszczyk et al.

DOI: https://doi.org/10.1101/2024.05.27.596068

Age and maturation stage linked consequences of fibrinogen on human oligodendroglia

April 2025

Gabriela J. Blaszczyk et al.

https://doi.org/10.1101/2024.05.27.596068

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Virally encoded single-chain antibody fragments targeting alpha-synuclein protect against motor impairments and neuropathology in a mouse model of synucleinopathy

September 2024

Anne-Marie Castonguay et al.

https://doi.org/10.1101/2024.09.09.612044

Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells

December 2024

Gabriela J Blaszczyk et al.

DOI: https://doi.org/10.1101/2024.12.17.628958

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

April 2024

T. Xu et al.

DOI:https://doi.org/10.1101/2024.04.26.587986

KCC2 as a novel biomarker and therapeutic target for motoneuron degenerative disease

August 2023

C. Sahara Khademullah, Julien Bourbonnais, Mathilde M. Chaineau, María José Castellanos-Montiel, Iason Keramidis, Alexandra Legault, Marie-Ève Paquet, Agessandro Abrahao, Lorne Zinman, Janice Robertson, Thomas M. Durcan, Melanie A. Woodin, Antoine G. Godin, Yves De Koninck

DOI: https://doi.org/10.1101/2023.08.24.554410

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STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein Oligomers

March 2025

Benjamin S. Rutledge et al.

https://doi.org/10.1101/2025.02.14.638390

Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activity

April 2025

Ghislaine Deyab et al.

https://doi.org/10.1101/2025.04.23.650231

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

September 2023

B. Vanderperre et al.

DOI: https://doi.org/10.1101/2023.09.29.560170

Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study

May 2024

S. Tullo et al.

DOI:https://doi.org/10.1101/2022.08.23.22278845

Image that represents the pre-print: A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

May 2023

Armin Bayati, Riham Ayoubi, Cornelia E. Zorca, Adriana Aguila, Chanshuai Han, Emily Banks, Emmanuelle Nguyen-Renou, Wen Luo, Irina Shlaifer, Esther Del Cid-Pellitero, Moein Yaqubi, Edward A. Fon, Jo Anne Stratton, Thomas M. Durcan, Patrick

Nahirney, Peter S. McPherson

DOI: 10.1101/2023.05.29.542776