Lisez nos pré-impressions ci-dessous.
Stress-adaptive biomaterials with tunable yielding architectures regulate organoid morphogenesis
Jan 2026
An automated workflow for quantifying the formation of synuclein aggregates in human dopaminergic neurons
Dec 2025
Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissue
Nov 2025
In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivity
Aug 2025
Age and maturation stage linked consequences of fibrinogen on human oligodendroglia
April 2025
Virally encoded single-chain antibody fragments targeting alpha-synuclein protect against motor impairments and neuropathology in a mouse model of synucleinopathy
September 2024
Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells
December 2024
Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins
April 2024
KCC2 as a novel biomarker and therapeutic target for motoneuron degenerative disease
August 2023
C. Sahara Khademullah, Julien Bourbonnais, Mathilde M. Chaineau, María José Castellanos-Montiel, Iason Keramidis, Alexandra Legault, Marie-Ève Paquet, Agessandro Abrahao, Lorne Zinman, Janice Robertson, Thomas M. Durcan, Melanie A. Woodin, Antoine G. Godin, Yves De Koninck
Deep Plasma Proteomics Coupled with Functional Genomics Reveals Drivers of Parkinson’s Disease Progression and Levodopa Response
Jan 2026
Therapeutic modulation of the calpastatin/calpain pathway restores calpain-mediated synaptic proteolysis and preserves motor neurons survival and function in C9orf72 ALS
Dec 2025
LRRK2 Kinase Mediates Increased GCase Activity in Microglia in Response to Proinflammatory Stimuli
Oct 2025
SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids
May 2025
STIP1/HOP Promotes the Formation of Cytotoxic α-Synuclein Oligomers
March 2025
Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activity
April 2025
A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans
September 2023
Sex-focused analyses of M83 A53T hemizygous mouse model with recombinant human alpha-synuclein preformed fibril injection identifies female resilience to disease progression: A combined magnetic resonance imaging and behavioural study
May 2024
A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons
May 2023
Armin Bayati, Riham Ayoubi, Cornelia E. Zorca, Adriana Aguila, Chanshuai Han, Emily Banks, Emmanuelle Nguyen-Renou, Wen Luo, Irina Shlaifer, Esther Del Cid-Pellitero, Moein Yaqubi, Edward A. Fon, Jo Anne Stratton, Thomas M. Durcan, Patrick
Nahirney, Peter S. McPherson
DOI: 10.1101/2023.05.29.542776
A high-content imaging workflow to screen for molecules that reduce cellular uptake of α-synuclein preformed fibrils
Dec 2025
N-terminal acetylation reduces α-synuclein pathology in models of Parkinson’s disease
Nov 2025
Design, synthesis and biological evaluation of novel [5,5]-fused thiazolidine/oxazolidine inhibitors for targeting prolyl oligopeptidase
Sept 2025
Cell type specific analysis of ALS-associated proteins reveals immune-regulated targets
April 2025
Glucosylceramide induced ectosomes propagate pathogenic α-synuclein in Parkinson’s disease
February 2025
Mutations in SOD1 induce ALS-related phenotypes in 3D iPSC-derived motor neuron (MN) spheroids
January 2025
Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924
January 2024
The functional and pathogenic consequences of fibrinogen on human oligodendroglia
June 2024