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Lisez nos publications et consultez les affiches et les présentations nous avons partagées lors de conférences scientifiques. Pour toute demande concernant nos publications,  s'il vous plaît écrivez-nous . 

Publications les plus récentes
Voir le menu déroulant sous Publications et affiches pour accéder les publications plus anciennes.

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The Use of a SOX10 Reporter Towards Ameliorating Oligodendrocyte Lineage Differentiation from Human Induced Pluripotent Stem Cells

March 2024

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Transcriptional dysregulation and impaired neuronal activity in FMR1 knock-out and Fragile X patients’ iPSC-derived models

August 2023

Image that represents the paper: Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

April 2023

Hooshmandi M et al.

DOI: 10.1101/2023.04.24.538123

Image that represents the paper: Structure-based design and characterization of Parkin-activating mutations

Structure-based design and characterization of Parkin-activating mutations

March 2023

Micheal Stevens et al. 

DOI: 10.26508/lsa.202201419

Image that represents the paper: An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

February 2023

Maria Jose Castellanos-Montiel et al.

DOI: 10.3390/cells12040545

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Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons

March 2024

Image that represents the paper: Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

July 2023

Englert L. et al.

DOI: 10.1002/lpor.202300443

Image that represents the paper: α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

April 2023

Benjamin Feller et al.

DOI: 10.1101/2023.01.28.526024

Image that represents the paper: Visualization of α-synuclein trafficking via nanogold labeling and electron microscopy

Visualization of α-synuclein trafficking via nanogold labeling and electron microscopy

February 2023

Armin Bayati et al. 

DOI: 10.1016/j.xpro.2023.102113

Image that represents the paper: Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

January 2023

Marie-France Dorion et al.

DOI: 10.1002/glia.24338

Image that represents the paper: MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

September 2023

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The next generation of tools and technologies for studying human neurons in a dish

April 2023

Durcan TM, Axtman AD.

DOI: 10.3389/fncel.2023.1196543

Image that represents the paper: Compressive molding of engineered tissues via thermoresponsive hydrogel devices

Compressive molding of engineered tissues via thermoresponsive hydrogel devices

March 2023

Image that represents the paper: Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

February 2023

Philip McGoldrick et al.

DOI: 10.1101/2021.10.20.465148

Affiches

Posters
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Development of in vitro ALS discovery andtranslational assays with patient-derived cells

Mathilde Chaineau, Vincent Soubannier, Lale Gursu, Anna Krystina Franco-Flores, Ghazal Haghi, María José Castellanos-Montiel
Sarah Lépine, Carol X-Q Chen, Valerio Piscopo, Narges Abdian and Thomas M. Durcan

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Studying the effects of NF subunit abnormalities in neuromuscular junction morphology and function

María José Castellanos-Montiel, Anna Krystina Franco-Flores, Sarah Lépine, Lale Gursu, Ghazal Haghi, Mathilde Chaineau, Carol X-Q Chen, Narges Abdian, Eric Deneault, Michael Nicouleau, Thomas M. Durcan

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Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

Andrea I. Krahn, Wolfgang E. Reintsch, Chanshuai Han, Emmanuelle Nguyen-Renou, Carol X.-Q. Chen, Wen Luo, Edward A. Fon, Thomas M. Durcan

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Nuclear phenotypes and astrogliosis in astrocytes derived from ALS SOD1(A4V)-mutated iPSCs

Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Sarah Lepine, Guy Rouleau, Thomas M. Durcan and Stefano Stifani

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Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease 

Indra Roy, Rhalena A. Thomas, Thomas M. Durcan

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Transcriptome-based in silico screening in human motor neurons with ALS-associated mutations in TARDBP/TDP-43

Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, Georgina Jiménez Ambriz, Dan Spiegelman, María José Castellanos-Montiel, Narges Abdian, Anna K.Franco-Flores, Ghazal Haghi, Lale Gursu, Mathilde Chaineau, and Thomas M. Durcan

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The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

Marie-France Dorion, Konstantin Senkevich, Moein Yaqubi, Wen Luo, Amber Wallis, Irina Shlaifer, Jack P. Antel, Ziv Gan-Or, Tim Bartel, Thomas M. Durvan, Luke M. Healy

Présentations

Image of Thomas Durcan presentation about iPSC
Presentations
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