Read our publications and view the posters and presentations we have shared at scientific meetings. For inquiries regarding our publications, please email us.

Most Recent Publications
See the drop down menu under Publications for yearly archives.

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

August 2025

Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, María José Castellanos-Montiel, Georgina Jiménez Ambriz, Dan Spiegelman, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, Lale Gursu, Michael R. Fiorini, Allison A. Dilliott, Sali M. K. Farhan, Mathilde Chaineau & Thomas M. Durcan

https://doi.org/10.1038/s41598-025-12147-8

Single cell RNA-seq to identify subpopulations of glial progenitors iniPSC-derived oligodendroglial lineage cultures

April 2025

Gabriela J. Blaszczyk, Valerio E. C. Piscopo, Taylor M. Goldsmith, Alexandra Chapleau, Julien Sirois, Geneviève Bernard, Jack P. Antel & Thomas M. Durcan

https://doi.org/10.1038/s41540-025-00515-z

Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells

July 2025

Gabriela J Blaszczyk, Abdulshakour Mohammadnia, Valerio E C Piscopo, Julien Sirois, Qiao-Ling Cui, Moein Yaqubi, Thomas M Durcan, Raphael Schneider, Jack P Antel

DOI: 10.1212/NXI.0000000000200407

Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson's Disease Using In Vitro Models

March 2025

Alexander Shtilbans, Elise Esneault, Florian Simon, Joseph R Mazzulli, Drew J Quiriconi, Dror Rom, Wolfgang E Reintsch, Andrea I Krahn, Thomas M Durcan

DOI: 10.3390/antiox14040396

Posters

Development of in vitro ALS discovery and
translational assays with patient-derived cells

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Mathilde Chaineau, Vincent Soubannier, Lale Gursu, Anna Krystina Franco-Flores, Ghazal Haghi, María José Castellanos-Montiel
Sarah Lépine, Carol X-Q Chen, Valerio Piscopo, Narges Abdian and Thomas M. Durcan

Studying the effects of NF subunit abnormalities in neuromuscular junction morphology and function

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María José Castellanos-Montiel, Anna Krystina Franco-Flores, Sarah Lépine, Lale Gursu, Ghazal Haghi, Mathilde Chaineau, Carol X-Q Chen, Narges Abdian, Eric Deneault, Michael Nicouleau, Thomas M. Durcan

Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

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Andrea I. Krahn, Wolfgang E. Reintsch, Chanshuai Han, Emmanuelle Nguyen-Renou, Carol X.-Q. Chen, Wen Luo, Edward A. Fon, Thomas M. Durcan

Nuclear phenotypes and astrogliosis in astrocytes derived from ALS SOD1(A4V)-mutated iPSCs

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Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Sarah Lepine, Guy Rouleau, Thomas M. Durcan and Stefano Stifani

Image that represents the poster: Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

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Indra Roy, Rhalena A. Thomas, Thomas M. Durcan

Transcriptome-based in silico screening in human motor neurons with ALS-associated mutations in TARDBP/TDP-43

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Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, Georgina Jiménez Ambriz, Dan Spiegelman, María José Castellanos-Montiel, Narges Abdian, Anna K.Franco-Flores, Ghazal Haghi, Lale Gursu, Mathilde Chaineau, and Thomas M. Durcan

The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

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Marie-France Dorion, Konstantin Senkevich, Moein Yaqubi, Wen Luo, Amber Wallis, Irina Shlaifer, Jack P. Antel, Ziv Gan-Or, Tim Bartel, Thomas M. Durvan, Luke M. Healy

Presentations

Image of Thomas Durcan presentation about iPSC

Presentations

Read our publications and view the posters and presentations we have shared at scientific meetings. For inquiries regarding our publications, please email us.

Most Recent Publications See the drop down menu under Publications for yearly archives.

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

Single cell RNA-seq to identify subpopulations of glial progenitors iniPSC-derived oligodendroglial lineage cultures

Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells

Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson's Disease Using In Vitro Models

Posters

Development of in vitro ALS discovery and translational assays with patient-derived cells

Studying the effects of NF subunit abnormalities in neuromuscular junction morphology and function

Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

Nuclear phenotypes and astrogliosis in astrocytes derived from ALS SOD1(A4V)-mutated iPSCs

Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

Transcriptome-based in silico screening in human motor neurons with ALS-associated mutations in TARDBP/TDP-43

The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

Presentations

Most Recent Publications
See the drop down menu under Publications for yearly archives.

Development of in vitro ALS discovery and
translational assays with patient-derived cells