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Read our 2023 publications below.

Original Papers
(scroll down to see posters)

Image that represents the paper: MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

MerTK is a mediator of alpha-synuclein fibril uptake by human microglia

September 2023

Image that represents the paper: Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

April 2023

Hooshmandi M et al.

DOI: 10.1101/2023.04.24.538123

Image that represents the paper: An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

February 2023

Maria Jose Castellanos-Montiel et al.

DOI: 10.3390/cells12040545

Image that represents the paper: Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

July 2023

Englert L. et al.

DOI: 10.1002/lpor.202300443

Image that represents the paper: α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

April 2023

Benjamin Feller et al.

DOI: 10.1101/2023.01.28.526024

Image that represents the paper: Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

January 2023

Marie-France Dorion et al.

DOI: 10.1002/glia.24338

Cortical Neurons 7 weeks FB media 2 bar

The next generation of tools and technologies for studying human neurons in a dish

April 2023

Durcan TM, Axtman AD.

DOI: 10.3389/fncel.2023.1196543

Image that represents the paper: Compressive molding of engineered tissues via thermoresponsive hydrogel devices

Compressive molding of engineered tissues via thermoresponsive hydrogel devices

March 2023

Image that represents the paper: Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

February 2023

Philip McGoldrick et al.

DOI: 10.1101/2021.10.20.465148

Posters

C-BIG Infographic

Development of an Open Science Collection of Patient-Derived iPSCs
for Studying Disease Mechanisms in Neurodegenerative Diseases

Carol XQ Chen, Taylor M Goldsmith, Nicolas Ferry, Narges Abdian, Zhipeng You, Michaël Nicouleau,
Marie-Noëlle Boivin, Lydiane Gaborieau, Peng Wang, Kevin LaFleur, Sophiya Enjambre, Jason Karamchandani,
Thomas M. Durcan

Image that represents the poster: Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

Screening for compounds that reduce alpha synuclein fibril load in iPSC-derived neuronal cells

Andrea I. Krahn, Wolfgang E. Reintsch, Chanshuai Han, Emmanuelle Nguyen-Renou, Carol X.-Q. Chen, Wen Luo, Edward A. Fon, Thomas M. Durcan

Image that represents the poster: Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease

Single-cell RNA sequence analysis of post-mortem midbrain tissue reveals altered glial cell function in Parkinson's disease 

Indra Roy, Rhalena A. Thomas, Thomas M. Durcan

Image that represents the poster: The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

The Mer tyrosine kinase mediates the internalization of alpha-synuclein fibrils by human microglia

Marie-France Dorion, Konstantin Senkevich, Moein Yaqubi, Wen Luo, Amber Wallis, Irina Shlaifer, Jack P. Antel, Ziv Gan-Or, Tim Bartel, Thomas M. Durvan, Luke M. Healy

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