Read our 2025-2026 publications below.

An automated workflow for quantifying the formation of synuclein aggregates in human dopaminergic neurons
October 2026
Chanshuai Han, Emmanuelle Nguyen-Renou, Faiza Benaliouad, Wen Luo, Carol X-Q. Chen, Aeshah Alluli, Lorenza Villegas, Lenore K. Beitel, Irina Shlaifer, Wolfgang E. Reintsch, Andrea I. Krahn, Esther Del Cid Pellitero, Edward A. Fon, & Thomas M. Durcan

N-terminal acetylation reduces synuclein pathology in models of Parkinson's disease
September 2026

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissue
July 2026

Age and Maturation Stage Linked Consequences of Fibrinogen on Human Oligodendroglia
March 2026
Gabriela J Blaszczyk, Chao Weng, Abdulshakour Mohammadnia, Qiao-Ling Cui, Arianna Giurleo, Adam M R Groh, Chloe Plouffe, Julien Sirois, Valerio E C Piscopo, Moein Yaqubi, Asad Taqvi, Erin Cassidy, Liam Callahan Martin, Jeffery A Hall, Roy W R Dudley, Myriam Srour, Stephanie E J Zandee, Wendy Klement, Sandra Larouche, Alexandre Prat, Thomas M Durcan, Jo Anne Stratton, Jack P Antel, G R Wayne Moore
DOI: 10.1002/jnr.70120

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids
Feb 2026

Developing a National Network for Leukodystrophy Research and Care in Canada
Dec 2025
Chapleau A, Le A, Simo J, Venkateswaran S, Lacaze-Masmonteil T, Piscopo VEC, Gauthier S, Villa Tobón F, Alam SS, Lentini L, Brais B, Ernst C, Mitchell JJ, Vinh DC, Zhou Y, Kennedy TE, Goloff N, Riham B, Chapleau R, Smith B, Greger V, Della Rocca J, Louis LM, Dike A, McIntyre LL, McIntyre DF, Tardif J, Lapointe É, Barnett J, Loignon V, Bardai G, Contant S, Durcan TM, La Piana R, Bernard G; as RareKids-CAN, RARE.Qc, CARELeuko.
DOI: 10.1212/NXG.0000000000200313.

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924
August 2025
Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, María José Castellanos-Montiel, Georgina Jiménez Ambriz, Dan Spiegelman, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, Lale Gursu, Michael R. Fiorini, Allison A. Dilliott, Sali M. K. Farhan, Mathilde Chaineau & Thomas M. Durcan

Single cell RNA-seq to identify subpopulations of glial progenitors iniPSC-derived oligodendroglial lineage cultures
April 2025
Gabriela J. Blaszczyk, Valerio E. C. Piscopo, Taylor M. Goldsmith, Alexandra Chapleau, Julien Sirois, Geneviève Bernard, Jack P. Antel & Thomas M. Durcan

Efficient cryopreservation of human midbrain organoids using conventional DMSO protocols with ice recrystallization inhibitors
September 2026
Ellyssa M. Walsh, Cecilia Rocha, Paula Lépine, Julien Sirois, Thomas M. Durcan &
Robert N. Be

A high-content imaging workflow to screen for molecules that reduce cellular uptake of α-synuclein preformed fibrils
August 2026

STIP1/HOP promotes the formation of cytotoxic α-synuclein oligomers
April 2026

LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation
March 2026

Glucosylceramide-induced ectosomes propagate pathogenic α-synuclein in Parkinson’s disease
Feb 2026
Julie Jacquemyn, Brian Marriott, Jinlan Chang, Ehlam Iftikhar, Kennedi Chik, Nathanael Y. J. Lee, Luis F. Rubio Atonal, Ceili Green, Jeremy Wong, Claudia Acevedo-Morantes, Carol X.-Q. Chen, Michael Nicouleau, Zhipeng You, Eric Deneault, Narges Abdian, Thomas M. Durcan, Jesse Jackson & Maria S. Ioannou

Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase
Dec 2025
Fiesel FC, Bustillos BA, Watzlawik JO, Chen CXQ, Berryer MH, Zhang J, Boneski PK, Hayes CS, Bredenberg JM, Deneault E, You Z, Abdien N, Aprahamian N, Goldsmith TM, Baninameh Z, Cocker LT, Zhang H, Goldberg MS, Fon EA, Trempe JF, Virdee S, Durcan TM, Springer W.

Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils
October 2025
Benoît Vanderperre, Amitha Muraleedharan, Marie-France Dorion, Frédérique Larroquette, Esther Del Cid Pellitero, Nishani Rajakulendran, Carol X.-Q. Chen, Roxanne Larivière, Charlotte Michaud-Tardif, Thomas Goiran, Rony Chidiac, Damien Lipuma, Graham MacLeod, Rhalena Thomas, Zhangjie Wang, Wolfgang E. Reintsch, Wen Luo, Irina Shlaifer, Fuming Zhang, Ke Xia, Zachary Steinhart, Robert J. Linhardt, Jean-François Trempe, Jian Liu, Thomas M. Durcan, Stephane Angers & Edward A. Fon

Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells
July 2025
Gabriela J Blaszczyk, Abdulshakour Mohammadnia, Valerio E C Piscopo, Julien Sirois, Qiao-Ling Cui, Moein Yaqubi, Thomas M Durcan, Raphael Schneider, Jack P Antel
DOI: 10.1212/NXI.0000000000200407

BetaII-spectrin gaps and patches emerge from the patterned assembly of the actin/spectrin membrane skeleton in human motor neuron axons
September 2026

Stress-adaptive biomaterials with tunable yielding architectures regulate organoid morphogenesis
July 2026

Neural cell state modulation by PARK2 and dopaminergic neuroprotection by small molecule Parkin agonism
April 2026

PAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis
March 2026
Jaskaran Singh , Léa Lescouzères , Charlotte Zaouter , Mathilde Chaineau , Ghazal Haghi , Thomas M Durcan & Shunmoogum A Patten

BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons
September 2025
Nahir Guadalupe Gazal, Maria Jose Castellanos-Montiel, Guillermina Bruno, Anna Kristina Franco-Flores, Sarah Lépine, Lale Gursu, Ghazal Haghi, Gilles Maussion, Agustín Anastasía, Mariano Bisbal, Ezequiel Axel Gorostiza, Thomas M Durcan, Nicolás Unsain

Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson's Disease Using In Vitro Models
March 2025
Alexander Shtilbans, Elise Esneault, Florian Simon, Joseph R Mazzulli, Drew J Quiriconi, Dror Rom, Wolfgang E Reintsch, Andrea I Krahn, Thomas M Durcan
DOI: 10.3390/antiox14040396



