Read our 2025-2026 publications below.
BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons
September 2025
Nahir Guadalupe Gazal, Maria Jose Castellanos-Montiel, Guillermina Bruno, Anna Kristina Franco-Flores, Sarah Lépine, Lale Gursu, Ghazal Haghi, Gilles Maussion, Agustín Anastasía, Mariano Bisbal, Ezequiel Axel Gorostiza, Thomas M Durcan, Nicolás Unsain
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Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson's Disease Using In Vitro Models
March 2025
Alexander Shtilbans, Elise Esneault, Florian Simon, Joseph R Mazzulli, Drew J Quiriconi, Dror Rom, Wolfgang E Reintsch, Andrea I Krahn, Thomas M Durcan​
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DOI: 10.3390/antiox14040396
Developing a National Network for Leukodystrophy Research and Care in Canada
Dec 2025
Chapleau A, Le A, Simo J, Venkateswaran S, Lacaze-Masmonteil T, Piscopo VEC, Gauthier S, Villa Tobón F, Alam SS, Lentini L, Brais B, Ernst C, Mitchell JJ, Vinh DC, Zhou Y, Kennedy TE, Goloff N, Riham B, Chapleau R, Smith B, Greger V, Della Rocca J, Louis LM, Dike A, McIntyre LL, McIntyre DF, Tardif J, Lapointe É, Barnett J, Loignon V, Bardai G, Contant S, Durcan TM, La Piana R, Bernard G; as RareKids-CAN, RARE.Qc, CARELeuko.
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DOI: 10.1212/NXG.0000000000200313.
Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924
August 2025
Sarah Lépine, Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, María José Castellanos-Montiel, Georgina Jiménez Ambriz, Dan Spiegelman, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, Lale Gursu, Michael R. Fiorini, Allison A. Dilliott, Sali M. K. Farhan, Mathilde Chaineau & Thomas M. Durcan
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Single cell RNA-seq to identify subpopulations of glial progenitors iniPSC-derived oligodendroglial lineage cultures
April 2025
Gabriela J. Blaszczyk, Valerio E. C. Piscopo, Taylor M. Goldsmith, Alexandra Chapleau, Julien Sirois, Geneviève Bernard, Jack P. Antel & Thomas M. Durcan
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Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase
Dec 2025
​Fiesel FC, Bustillos BA, Watzlawik JO, Chen CXQ, Berryer MH, Zhang J, Boneski PK, Hayes CS, Bredenberg JM, Deneault E, You Z, Abdien N, Aprahamian N, Goldsmith TM, Baninameh Z, Cocker LT, Zhang H, Goldberg MS, Fon EA, Trempe JF, Virdee S, Durcan TM, Springer W.​
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Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils
October 2025
Benoît Vanderperre, Amitha Muraleedharan, Marie-France Dorion, Frédérique Larroquette, Esther Del Cid Pellitero, Nishani Rajakulendran, Carol X.-Q. Chen, Roxanne Larivière, Charlotte Michaud-Tardif, Thomas Goiran, Rony Chidiac, Damien Lipuma, Graham MacLeod, Rhalena Thomas, Zhangjie Wang, Wolfgang E. Reintsch, Wen Luo, Irina Shlaifer, Fuming Zhang, Ke Xia, Zachary Steinhart, Robert J. Linhardt, Jean-François Trempe, Jian Liu, Thomas M. Durcan, Stephane Angers & Edward A. Fon
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Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells
July 2025
Gabriela J Blaszczyk, Abdulshakour Mohammadnia, Valerio E C Piscopo, Julien Sirois, Qiao-Ling Cui, Moein Yaqubi, Thomas M Durcan, Raphael Schneider, Jack P Antel​
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DOI: 10.1212/NXI.0000000000200407