Read about the latest updates happening at the EDDU
Read the EDDU's monthly newsletter to learn more about the latest events and achievements happening at the EDDU!
Click here to read the Winter 2022 newsletter.
Image of a dopaminergic neuron
By Chanshuai Han
The Neuro's EDDU receives Canada Foundation for Innovation funding.
Congratulations to Dr. Thomas Durcan, Director of the Early Drug Discovery Unit (EDDU) at the Neuro, whose project was funded through the John R. Evans Leaders Fund.
Learn more by reading the full article here.
iPSC Seminar Series at the EDDU
Supported by Healthy Brains for Healthy Lives and STEMCELL Technologies, The Neuro’s iPSC Seminar Series welcomes trainees and senior scientists working with induced pluripotent stem cells (iPSCs) to present their cutting-edge research. The Seminar Series intends to foster collaborations within the network of laboratories working with iPSCs in Montreal, Canada, and around the world.
Watch our new video to learn more! To get involved in the seminar series, or to learn about past speakers, please visit our website.
The EDDU is on Instagram! Check out our latest posts below.
EDDU Video Spotlight
Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing
Congratulations to Carol Chen, iPSC Colony manager at the EDDU, and to everyone else involved for their recent publication in Stem Cell Research. Click the link below to read the full article.
Auto-qPCR: A Python-based web app for automated and reproducible analysis of qPCR data
Gilles Maussion and others have developed an open-source Python software to automate processing of result spreadsheets from qPCR machines, employing calculations usually performed manually. Auto-qPCR is a tool that saves time when computing qPCR data, helping to ensure reproducibility of qPCR experiment analyses.
Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease
We are excited to announce that the article by Vincent Soubannier of the EDDU and others,"Rapid Generation of Ventral
Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous
Mechanisms of Lower Motor Neuron Disease", has been published in Cells as part
of the Special Issue Cell-Based Models of Diseases for Drug Discovery.
Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy
Here, Nguyen-Vi Mohamed and others use three-dimensional midbrain organoids, differentiated from human-induced pluripotent stem cells derived from patients carrying a triplication of the SNCA gene and from CRISPR/Cas9 corrected isogenic control iPSCs. These human midbrain organoids recapitulate key feature of α-synuclein pathology observed in the brains of patients with synucleinopathies.