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Read about the latest updates happening at the EDDU

September 2023

We are very happy to share that Marie-France Dorion's paper entitled "MerTK is a mediator of alpha-synuclein fibril uptake by human microglia" has just been published in Brain.

Congratulations to everyone involved in this paper!

Click on the link to access the publication: https://lnkd.in/eakD96E3

September 2023

Watch the EDDU's latest video "Open Science with Guada and Maria" to discover how the lab builds collaborations around the world to advance research on stem cells and brain disorders.

Meet Guada, a PhD student at Dr. Nicolas Unsain's lab, in Argentina, who worked with our lab's PhD student Maria, on characterizing membrane-associated periodic skeleton (MPS) in different iPSC-derived cells.

 

 Click the following link for the video: https://www.youtube.com/watch?v=oSLUH9W_obk 

August 2023

The Neuro’s EDDU is pleased to share our updated protocol for generating dopaminergic neurons from iPSCs through the use of a Microfabricated Disk. 

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You can access the protocol here: https://zenodo.org/record/8256637 

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Image of an iPSC-derived microglia 

by Marie-France Dorion

Read the EDDU's monthly newsletter to learn more about the latest events and achievements happening at the EDDU!

Click here to read the August 2023 newsletter.

The Neuro-CERVO Alliance for Drug Discovery (NCADD) is pleased to share its partnership with AI company Simmunome to better understand mechanisms of neurological disease and accelerate drug development. The Neuro’s EDDU joined the newly established NCADD initiative in April, and since then have worked collectively towards the initiative’s goal of catalyzing public-private collaborations in Quebec’s life sciences sector.

To this effect, NCADD’s partnership with Montreal-based private company Simmunome will employ their AI expertise to untangle biological pathways and biomarkers of neurological and psychiatric disorders, working towards potential therapeutic targets for these devastating conditions.

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The Neuro’s EDDU is proud to share that Carol Chen, Research Assistant at the Early Drug Discovery Unit, has been awarded the 2023 Champion Award for Research Staff, alongside Claire Magnussen, Nikhil Bhagwat, and Samir Das. This award is a part of The Neuro Open Science Internal Awards, supported by Tanenbaum Open Science Institute to recognize researchers, staff, graduate and undergraduate students at The Neuro who have shown leadership and creativity in Open Science, inspiring peers and fostering a community of Open Science practice. Congratulations to all the awardees on this well deserved recognition of your work and commitment to Open Science!  

The Neuro’s EDDU is proud to share that Thomas

Durcan, the Director of the EDDU, is co-principal

investigator of the new testing platform TRIDENT. In

a partnership between McGill University and

Western University, TRIDENT strives to identify

promising therapeutics against neurodegenerative

diseases such as Alzheimer’s and Parkinson’s earlier,

redirecting efforts and funding to the most promising

therapeutics. The New Frontiers in Research Fund’s

transformation stream has granted TRIDENT $24

million over six years.

Through advanced testing models, and a unique

focus on cognition, the platform will help bring drugs

with the most therapeutic potential to market and

assist researchers to assess whether these drugs

deliver the health outcomes anticipated.

 

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Image of an iPSC-derived gut organoid

by Faiza Benaliouad

Read the EDDU's monthly newsletter to learn more about the latest events and achievements happening at the EDDU!

Click here to read the May 2023 newsletter.

The Neuro’s EDDU is proud to be part of the Neuro-CERVO Alliance for Drug Discovery in Brain Diseases (NCADD) initiative. NCADD’s vision is to embrace patients’ heterogeneity to develop effective treatment to neurological conditions such as Parkinson’s disease, schizophrenia and bipolar disorder. Through a unique unbiased scientific approach, combining deep patients’ characterization and artificial intelligence, our mission is to address major challenges in the neuroscience field such as finding biomarkers for neurological disorders, enabling drug target discovery, and facilitating the development of personalized therapies. NCADD’s core objective is to be a catalyst for public-private collaborations and for growth of the life science sector in Quebec.

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To learn more, go to: https://www.neuro-cervo.org/ 

We are happy to announce our next virtual iPSC workshop which will take place on June 21st and 22nd. This is an excellent opportunity to learn about working with human induced pluripotent stem cells (hiPSCs) and how they can be differentiated into neuronal cell types.

The application deadline is June 2nd.

 

To register for the workshop, go to: https://www.surveymonkey.com/r/LDJ59Z8.

 

Please note that the completion of the on-demand neural induction course is a prerequisite to attending this course if accepted. The link to register for this course is https://www.stemcell.com/forms/neural-induction-on-demand-training.html

The EDDU is on Instagram! Check out our latest posts below.

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EDDU Video Spotlight

Publication Updates

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Loss of C9orf72 perturbs the Ran-GTPase gradient and generates compositionally diverse cytoplasmic Importin β-1 granules in motor and cortical neurons in vivo

February 2023

Philip McGoldrick et al.

DOI: 10.1101/2021.10.20.465148

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An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

February 2023

Maria Jose Castellanos-Montiel et al.

DOI: 10.3390/cells12040545

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Systematic comparison of culture media uncovers phenotypic shift of primary human microglia defined by reduced reliance to CSF1R signaling

January 2023

Marie-France Dorion et al.

DOI: 10.1002/glia.24338

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