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Read our 2021-2022 publications below.

Original Papers
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The identification of potent and selective antibodies for Serine/threonine-protein kinase TBK1, for use in immunoblot, immunofluorescence and immunoprecipitation

June 2022

Walaa Alshafie et al.

DOI: 10.1101/2022.06.03.494699


Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing

May 2022

Carol X.-Q. Chen  et al. 

DOI: 10.1016/j.scr.2022.102806


FOXG1 dose tunes cell proliferation dynamics in human forebrain progenitor cells

February 2022

Nuwan C. Hettige et al. 

DOI: 10.1016/j.stemcr.2022.01.010


Auto-qPCR: A Python-based web app for automated and reproducible analysis of qPCR data

October 2021

Gilles Maussion et al.

DOI: 10.1038/s41598-021-99727-6


Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria 

January 2022

Marta Vranas et al.

DOI: 10.1098/rsob.210255

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Identification of amyloid beta in small extracellular vesicles via Raman spectroscopy

June 2021

Meruyert Imanbekova et al.

DOI: 10.1039/d1na00330e

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Generation of human midbrain organoids from induced pluripotent stem cells

February 2021

Nguyen-Vi Mohamed et al. 

DOI: 10.12688/mniopenres.12816.2

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Generation of patient-derived pluripotent stem cell-lines and CRISPR modified isogenic controls with mutations in the Parkinson’s associated GBA gene

October 2022

Carol X.-Q. Chen  et al. 

DOI: 10.1016/j.scr.2022.102919


A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease

March 2022

Morgan Bérard et al. 

DOI: 10.1371/journal.pbio.3001578


Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease

January 2022

Vincent Soubannier et al. 

DOI: 10.3390/cells11030399

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Midbrain organoids with an SNCA gene triplication model key features of synucleinopathy

September 2021

Nguyen-Vi Mohamed et al. 

DOI: 10.1101/2021.04.12.439480


A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types

July 2021

Carol X.-Q. Chen et al.

DOI: 10.3390/mps4030050

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Optogenetic-Mediated Spatiotemporal Control of α-Synuclein Aggregation Mimics Lewy Body Formation and Triggers Neurodegeneration

May 2021

Morgan Berard et al.

DOI: 10.2139/ssrn.3854707


Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models

February 2021

Jack Wuyang Jin et al.

DOI: 10.1038/s42003-021-01746-6


Rapid macropinocytic transfer of α-synuclein to lysosomes

July 2022

Armin Bayati et al. 

DOI: 10.1016/j.celrep.2022.111102


An Approach to Measuring Protein Turnover in Human Induced Pluripotent Stem Cell Organoids by Mass Spectrometry

March 2022

Jing Dong et al. 

DOI: 10.1016/j.ymeth.2022.03.011


Hydrogel Mechanics Influence the Growth and Development of Embedded Brain Organoids

January 2022

Camille Cassel de Camps et al. 

DOI: 10.1021/acsabm.1c01047


A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis. 

July 2022

Eric Deneault et al.

DOI: 10.1016/j.ymeth.2021.09.002


Microfabricated disk technology: rapid scale up in midbrain organoid generation

July 2021

Nguyen-Vi Mohamed et al.

DOI: 10.1016/j.ymeth.2021.07.008


Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation

March 2021

Omid Tavassoly et al.

DOI: 10.1007/s13311-021-01017-6



TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

December 2022

Sarah Lépine, Maria José Castellanos-Montiel, Thomas Durcan

DOI: 10.1186/s40035-022-00331-z

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Post-transcriptional and Post-translational Modifications of Primary Cilia: How to fine tune your neuronal antenna

February 2022

Cecilia Rocha and Panagiotis Prinos

DOI: 10.3389/fncel.2022.809917


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A convolutional neural network distinguishing between Parkinson's disease and healthy cells using microscopy images

Eddie Cai, Wolfgang Reintsch, Chanshaui Han, Sneha Shinde, Roxanne Larivière, Andrea Krahn, Carol X.Q. Chen, Emmanualle Nguyen-Renou, Anna Franco-Flores, Thomas M. Durcan, Edward A. Fon, Rhalena A. Thomas

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Standardized QC workflow foranalyzing the quality and differentiation potential of human iPSCs

 Carol X-Q. Chen, Narges Abdian, Gilles Maussion, Rhalena A. Thomas, Iveta Demirova, Eddie Cai, Edward A. Fon, Thomas M. Durcan

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