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Read our pre-prints below.

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Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

January 2024

Sarah Lépine,  Gilles Maussion, Alexandria Schneider, Angela Nauleau-Javaudin, María José Castellanos-Montiel, Georgina Jiménez Ambriz, Dan Spiegelman, Narges Abdian, Anna Krystina Franco-Flores, Ghazal Haghi, Lale Gursu, Mathilde Chaineau, Thomas Durcan

DOI: https://doi.org/10.1101/2024.01.30.578100

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KCC2 as a novel biomarker and therapeutic target for motoneuron degenerative disease

August 2023

C. Sahara Khademullah, Julien Bourbonnais, Mathilde M. Chaineau, María José Castellanos-Montiel, Iason Keramidis, Alexandra Legault, Marie-Ève Paquet, Agessandro Abrahao, Lorne Zinman, Janice Robertson, Thomas M. Durcan, Melanie A. Woodin, Antoine G. Godin, Yves De Koninck

 

DOI: https://doi.org/10.1101/2023.08.24.554410

Image that represents the pre-print: Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to progressive synaptic dysfunction in human iPSC-derived motor neurons

Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to progressive synaptic dysfunction in human iPSC-derived motor neurons

March 2023

Sarah Lépine et al.

DOI: 10.1101/2023.03.22.533562

Image that represents the pre-print: Presymptomatic neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy

Presymptomatic neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy

October 2022

Stephanie Tullo et al.

DOI: 10.1101/2022.10.12.511820

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The Use of a SOX10 Reporter Towards Ameliorating Oligodendrocyte Lineage Differentiation from Human Induced Pluripotent Stem Cells

December 2023

Valerio E.C. Piscopo, Alexandra Chapleau, Gabriela J Blaszczyk, Julien Sirois, Zhipeng You, Vincent Soubannier, Geneviève Bernard, Jack P Antel, Thomas Durcan

DOI: https://doi.org/10.1101/2023.12.01.569591

Image that represents the pre-print: Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications

July 2023

Riham Ayoubi, Joel Ryan, Maryam Fotouhi, Walaa Alshafie, Sara Gonzalez Bolivar, Vera Ruiz Moleon, Wolfgang Reintsch, Peter Eckmann, Donovan Worrall, Ian McDowell, Kathleen Southern, Thomas M. Durcan, Claire M. Brown, Anita Bandrowski, Harvinder S. Virk, Aled M Edwards, Peter S McPherson, Carl Laflamme

DOI: 10.1101/2023.06.01.543292

Image that represents the pre-print: Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice

Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice

December 2022

Lenka Shorova et al.

DOI: 10.1101/2022.12.21.521125

Image that represents the pre-print: Early nuclear phenotypes and reactive transformation in human iPSC

Early nuclear phenotypes and reactive transformation in human iPSC

October 2023

Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Sarah Lepine, David Kalaydjian, Ghazal Haghi, Guy Rouleau, Thomas M. Durcan, Stefano Stifani

DOI: 10.1101/2023.06.01.543292

Image that represents the pre-print: A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons

May 2023

Armin Bayati, Riham Ayoubi, Cornelia E. Zorca, Adriana Aguila, Chanshuai Han, Emily Banks, Emmanuelle Nguyen-Renou, Wen Luo, Irina Shlaifer, Esther Del Cid-Pellitero, Moein Yaqubi, Edward A. Fon, Jo Anne Stratton, Thomas M. Durcan, Patrick

Nahirney, Peter S. McPherson

DOI: 10.1101/2023.05.29.542776

Image that represents the pre-print: CelltypeR: A framework to identify and characterize cell types in human midbrain organoids using flow cytometry

CelltypeR: A framework to identify and characterize cell types in human midbrain organoids using flow cytometry

November 2022

Rhalena A. Thomas et al.

DOI: 10.1101/2022.11.11.516066

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